Evaluation of Oxidatively Generated Damage to DNA and Proteins in Rat Liver Induced by Exposure to Technetium Radioisotope 99m and Protective Role of Angelica archangelica and Ginkgo biloba

This study aimed to investigate the oxidatively generated damage to DNA and proteins induced by internal irradiation with the radiopharmaceutical administration of Technetium ( Tc) in rat liver and to 99m 99m evaluate the radioprotective effect of Angelica archangelica and Ginkgo biloba flavonoids. Sixty adult male Wistar rats were classified into six equal groups. Group 1 served as normal control rats. Group 2 represents animals which received 1 mCi of Tc only. Groups 3 and 4 represent animals which received Angelica and 99m Gingko for seven days, respectively. Groups 5 and 6 represent animals which received 1 mCi of Tc once after 99m application of Angelica and Gingko for seven days, respectively. Pretreatment with Angelica and Ginkgo prior Tc irradiation showed inhibitory effects against DNA damage, protein oxidation and reduced antioxidant 99m capacity. The results indicate a protective role for Angelica and Ginkgo against the genetic damage and oxidative stress induced by radiopharmaceutical administration. This study has important implications for patients undergoing nuclear medicine procedures.